Optimal oxygen saturation target for preterm infants

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Target ranges of oxygen saturation in extremely preterm infants.

BACKGROUND Previous studies have suggested that the incidence of retinopathy is lower in preterm infants with exposure to reduced levels of oxygenation than in those exposed to higher levels of oxygenation. However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes. METHODS We performed a randomized trial with a 2-by-2 fac...

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Target Ranges of Oxygen Saturation in Extremely Preterm Infants

*The authors are listed in the Appendix. The affiliations of the authors and other investigators in the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) Study Group of the Neonatal Research Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development are listed in the Appendix. Address reprint requests to Dr. Waldemar A. Carlo at the...

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Oxygen saturation and outcomes in preterm infants.

BACKGROUND The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a rang...

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Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis.

IMPORTANCE The optimal oxygen saturation (SpO2) target for extremely preterm infants is unknown. OBJECTIVE To systematically review evidence evaluating the effect of restricted vs liberal oxygen exposure on morbidity and mortality in extremely preterm infants. DATA SOURCES MEDLINE, PubMed, CENTRAL, and CINAHL databases from their inception to March 31, 2014, and abstracts submitted to Pedia...

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Appropriate levels of oxygen saturation for preterm infants.

Although oxygen is probably the most common therapy delivered to small or sick newborns in the past 75 years, what constitutes appropriate oxygenation for these infants remains highly controversial. The lack of direct evidence, in the form of randomised trials, of the effects of different oxygen levels on meaningful, long-term outcomes has fuelled this controversy and contributed to the signifi...

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ژورنال

عنوان ژورنال: Journal of Paediatrics and Child Health

سال: 2016

ISSN: 1034-4810

DOI: 10.1111/jpc.13257